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Understand Systemic Immune-Inflammation Index (SII)

Systemic Immune-Inflammation Index (SII)

Immunity & allergy markers

What the test generally measures, and what to ask about it.

Longetic keeps every lab and record you’ve had organized and easy to find, so your own Systemic Immune-Inflammation Index (SII) values sit together on one chart and you walk into your next appointment prepared.

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Updated Jul 13, 2026

What is Systemic Immune-Inflammation Index (SII)?

A calculated index combining platelets, neutrophils, and lymphocytes into a single marker of systemic inflammation.

SII is a calculated value from a routine CBC: it multiplies your platelet count by your neutrophil count and divides by your lymphocyte count - (platelets times neutrophils) divided by lymphocytes. A higher SII can be associated with a stronger systemic inflammatory state and, in research, less favorable outcomes, a lower value can be associated with a calmer immune profile. It is a general signal, not a diagnosis.

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References

Official source "Systemic immune-inflammation index and prognosis (Hu, Clin Cancer Res 2014)" PubMed. pubmed.ncbi.nlm.nih.gov/25271081.

About our sources

Clinical / professional

Medical societies, specialty colleges, and professional associations whose consensus statements reflect clinical practice standards.

Peer-reviewed research

Original research articles and systematic reviews published in indexed journals and verified through PubMed or DOI.

History of updates

Published · Jul 13, 2026
First published, calculated index, formula + sources independently fact-checked.

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