Systemic Immune-Inflammation Index (SII)
Immunity & allergy markersWhat the test generally measures, and what to ask about it.
Longetic keeps every lab and record you’ve had organized and easy to find, so your own Systemic Immune-Inflammation Index (SII) values sit together on one chart and you walk into your next appointment prepared.
What is Systemic Immune-Inflammation Index (SII)?
A calculated index combining platelets, neutrophils, and lymphocytes into a single marker of systemic inflammation.
SII is a calculated value from a routine CBC: it multiplies your platelet count by your neutrophil count and divides by your lymphocyte count - (platelets times neutrophils) divided by lymphocytes. A higher SII can be associated with a stronger systemic inflammatory state and, in research, less favorable outcomes, a lower value can be associated with a calmer immune profile. It is a general signal, not a diagnosis.
This glossary entry is for informational purposes only and is not a substitute for professional medical advice. Read our Terms of Use.
References
About our sources
Official sources
Government health agencies, national institutes, and intergovernmental bodies whose guidelines carry regulatory or policy weight.
Clinical / professional
Medical societies, specialty colleges, and professional associations whose consensus statements reflect clinical practice standards.
Peer-reviewed research
Original research articles and systematic reviews published in indexed journals and verified through PubMed or DOI.
