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Understand Systemic Inflammation Response Index (SIRI)

Systemic Inflammation Response Index (SIRI)

Immunity & allergy markers

What the test generally measures, and what to ask about it.

Longetic keeps every lab and record you’ve had organized and easy to find, so your own Systemic Inflammation Response Index (SIRI) values sit together on one chart and you walk into your next appointment prepared.

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Updated Jul 13, 2026

What is Systemic Inflammation Response Index (SIRI)?

A calculated index combining neutrophils, monocytes, and lymphocytes into a single marker of systemic inflammation.

SIRI is a calculated value from a routine CBC: it multiplies your neutrophil count by your monocyte count and divides by your lymphocyte count - (neutrophils times monocytes) divided by lymphocytes. A higher SIRI can be associated with greater systemic inflammation and, in research, less favorable outcomes, a lower value can be associated with a more balanced immune state. It is a general signal, not a diagnosis.

This glossary entry is for informational purposes only and is not a substitute for professional medical advice. Read our Terms of Use.

References

Official source "A novel systemic inflammation response index (SIRI) and survival (Qi, Cancer 2016)" PubMed. pubmed.ncbi.nlm.nih.gov/27152949.

About our sources

Clinical / professional

Medical societies, specialty colleges, and professional associations whose consensus statements reflect clinical practice standards.

Peer-reviewed research

Original research articles and systematic reviews published in indexed journals and verified through PubMed or DOI.

History of updates

Published · Jul 13, 2026
First published, calculated index, formula + sources independently fact-checked.

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