Systemic Inflammation Response Index (SIRI)
Immunity & allergy markersWhat the test generally measures, and what to ask about it.
Longetic keeps every lab and record you’ve had organized and easy to find, so your own Systemic Inflammation Response Index (SIRI) values sit together on one chart and you walk into your next appointment prepared.
What is Systemic Inflammation Response Index (SIRI)?
A calculated index combining neutrophils, monocytes, and lymphocytes into a single marker of systemic inflammation.
SIRI is a calculated value from a routine CBC: it multiplies your neutrophil count by your monocyte count and divides by your lymphocyte count - (neutrophils times monocytes) divided by lymphocytes. A higher SIRI can be associated with greater systemic inflammation and, in research, less favorable outcomes, a lower value can be associated with a more balanced immune state. It is a general signal, not a diagnosis.
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References
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Official sources
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Medical societies, specialty colleges, and professional associations whose consensus statements reflect clinical practice standards.
Peer-reviewed research
Original research articles and systematic reviews published in indexed journals and verified through PubMed or DOI.
