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Understand FIB-4 Index (Fibrosis-4)

FIB-4 Index (Fibrosis-4)

Liver markers

What the test generally measures, and what to ask about it.

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Updated Jul 13, 2026

What is FIB-4 Index (Fibrosis-4)?

A calculated score using age and routine blood tests to estimate the likelihood of significant liver scarring (fibrosis).

FIB-4 is a calculated value: it combines your age, two liver enzymes (AST and ALT), and your platelet count using (Age times AST) divided by (Platelets times the square root of ALT). It was developed as a simple, non-invasive way to gauge liver scarring without a biopsy. A higher FIB-4 can be associated with a greater likelihood of advanced fibrosis, a low value makes advanced scarring less likely. It is a risk estimate that guides further evaluation, not a diagnosis.

This glossary entry is for informational purposes only and is not a substitute for professional medical advice. Read our Terms of Use.

References

Official source "Development of a simple noninvasive index to predict significant fibrosis (FIB-4, Sterling 2006)" PubMed. pubmed.ncbi.nlm.nih.gov/16729309.

About our sources

Clinical / professional

Medical societies, specialty colleges, and professional associations whose consensus statements reflect clinical practice standards.

Peer-reviewed research

Original research articles and systematic reviews published in indexed journals and verified through PubMed or DOI.

History of updates

Published · Jul 13, 2026
First published, calculated index, formula + sources independently fact-checked.

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