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Understand Thyroid-Stimulating Immunoglobulin (TSI)

Thyroid-Stimulating Immunoglobulin (TSI)

Hormone markers

What the test generally measures, and what to ask about it.

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Summarize with AI
Updated Jul 13, 2026

What is Thyroid-Stimulating Immunoglobulin (TSI)?

A type of antibody that specifically stimulates the thyroid, driving it to make more hormone.

Thyroid-stimulating immunoglobulin is an antibody that acts like thyroid-stimulating hormone and pushes the thyroid to make extra hormone. Higher levels can be associated with Graves disease and its overactive thyroid, and the test may also help evaluate thyroid eye disease or thyroid activity in pregnancy. TSI measures the stimulating action specifically, so it is related to but not the same as the broader TSH receptor antibody test.

This glossary entry is for informational purposes only and is not a substitute for professional medical advice. Read our Terms of Use.

References

Clinical "Thyroid Antibodies" MedlinePlus (NIH/NLM). medlineplus.gov/lab-tests/thyroid-antibodies.
"Thyroid Function Tests" American Thyroid Association. www.thyroid.org/thyroid-function-tests.

About our sources

Clinical / professional

Medical societies, specialty colleges, and professional associations whose consensus statements reflect clinical practice standards.

Peer-reviewed research

Original research articles and systematic reviews published in indexed journals and verified through PubMed or DOI.

History of updates

Published · Jul 13, 2026
First published, written and independently fact-checked against the cited sources.

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