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Understand SDMA (Symmetric Dimethylarginine)

SDMA (Symmetric Dimethylarginine)

Heart & circulation markers

What the test generally measures, and what to ask about it.

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Updated Jul 13, 2026

What is SDMA (Symmetric Dimethylarginine)?

A close cousin of ADMA that the body clears mainly through the kidneys.

SDMA is formed alongside ADMA when the body recycles certain proteins, but it is removed almost entirely by the kidneys. Because of that, higher levels are most often associated with reduced kidney clearance, and some research has also linked it with cardiovascular risk in people with kidney disease. This is an advanced marker that is not part of a routine panel and is usually measured only in specialized research or kidney and heart evaluations.

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References

Peer-reviewed "Dimethylarginines ADMA and SDMA: the real water-soluble small toxins?" PubMed. doi.org/10.1016/j.semnephrol.2014.02.003.

About our sources

Clinical / professional

Medical societies, specialty colleges, and professional associations whose consensus statements reflect clinical practice standards.

Peer-reviewed research

Original research articles and systematic reviews published in indexed journals and verified through PubMed or DOI.

History of updates

Published · Jul 13, 2026
First published, written and independently fact-checked against the cited sources.

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