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Understand ADMA (Asymmetric Dimethylarginine)

ADMA (Asymmetric Dimethylarginine)

Heart & circulation markers

What the test generally measures, and what to ask about it.

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Updated Jul 13, 2026

What is ADMA (Asymmetric Dimethylarginine)?

A small molecule made when the body breaks down certain proteins, and it can interfere with how blood vessels relax.

ADMA is a naturally occurring compound that can block the enzyme that helps your blood vessels make nitric oxide, a signal that lets them relax and widen. Higher levels have been associated in research with stiffer, less flexible blood vessels and with a greater long-term risk of heart and circulation problems, and levels also tend to rise when the kidneys are not clearing it well. This is an advanced, research-oriented marker that is not part of a routine blood panel.

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References

Peer-reviewed "Dimethylarginines ADMA and SDMA: the real water-soluble small toxins?" PubMed. doi.org/10.1016/j.semnephrol.2014.02.003.

About our sources

Clinical / professional

Medical societies, specialty colleges, and professional associations whose consensus statements reflect clinical practice standards.

Peer-reviewed research

Original research articles and systematic reviews published in indexed journals and verified through PubMed or DOI.

History of updates

Published · Jul 13, 2026
First published, written and independently fact-checked against the cited sources.

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