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Understand Free PSA

Free PSA

Hormone markers

What the test generally measures, and what to ask about it.

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Updated Jul 13, 2026

What is Free PSA?

The portion of PSA in the blood that is not bound to other proteins, measured as a follow-up when total PSA is elevated.

PSA circulates in two forms, bound to proteins and unbound (free); free PSA measures just the unbound part. It is usually a follow-up test in men whose total PSA is elevated, used to help decide whether a prostate biopsy is worthwhile. On its own the free PSA number means little; it is meaningful mainly as part of the free-to-total ratio (percent-free PSA). Like total PSA, it applies only to men and does not diagnose cancer by itself.

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References

Clinical "Prostate-specific antigen (PSA) blood test" MedlinePlus Medical Encyclopedia (NIH/NLM). medlineplus.gov/ency/article/003346.htm.
"Prostate-Specific Antigen (PSA) Test" National Cancer Institute (NIH). www.cancer.gov/types/prostate/psa-fact-sheet.

About our sources

Clinical / professional

Medical societies, specialty colleges, and professional associations whose consensus statements reflect clinical practice standards.

Peer-reviewed research

Original research articles and systematic reviews published in indexed journals and verified through PubMed or DOI.

History of updates

Published · Jul 13, 2026
First published; written and independently fact-checked against the cited sources.

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