Understand Total PSA (Prostate-Specific Antigen)

Total PSA (Prostate-Specific Antigen)

Here’s what it reflects — and what to do about it.

Longetic pulls together every lab and record you’ve had, follows how Total PSA (Prostate-Specific Antigen) changes over time, and explains what’s shifting — so you walk into your next appointment prepared, with reminders for retests along the way.

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Updated Jul 13, 2026

What is Total PSA (Prostate-Specific Antigen)?

A protein made by the prostate gland whose blood level is used to help screen for and monitor prostate conditions in men.

PSA is a protein produced by both normal and cancerous prostate cells, so it applies to men. A higher level can be associated with prostate cancer, but it can also rise with a benign enlarged prostate, prostate infection, recent ejaculation or exercise, or a recent procedure, so it is not a diagnosis on its own. There is no single cutoff that means cancer; PSA is also widely used to watch for recurrence after prostate cancer treatment. Because screening carries a real chance of false positives and overtreatment, U.S. guidance frames PSA screening as an individual decision to discuss with a doctor (for men 55-69), and it is not recommended at age 70 and older.

What to know about Total PSA (Prostate-Specific Antigen)

Understanding Total PSA (Prostate-Specific Antigen) means knowing what it reflects, what tends to move it, and the signs that suggest it’s worth a closer look — so you can bring the right questions to your next appointment.

This glossary entry is for informational purposes only and is not a substitute for professional medical advice. Read our Medical Disclaimer.

References

"Prostate Cancer: Screening" U.S. Preventive Services Task Force (USPSTF). www.uspreventiveservicestaskforce.org/uspstf/recommendation/prostate-cancer-screening.
"Prostate-Specific Antigen (PSA) Test" National Cancer Institute (NIH). www.cancer.gov/types/prostate/psa-fact-sheet.

About our sources

Clinical / professional

Medical societies, specialty colleges, and professional associations whose consensus statements reflect clinical practice standards.

Peer-reviewed research

Original research articles and systematic reviews published in indexed journals and verified through PubMed or DOI.

History of updates

Published · Jul 13, 2026
First published; written and independently fact-checked against the cited sources.

Track your Total PSA (Prostate-Specific Antigen) over time with Longetic

Upload a lab, and Longetic reads it, explains it, and reminds you when it's time to re-check — so nothing slips between visits.