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Understand Neutrophil-to-HDL Ratio (NHR)

Neutrophil-to-HDL Ratio (NHR)

Immunity & allergy markers

What the test generally measures, and what to ask about it.

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Updated Jul 13, 2026

What is Neutrophil-to-HDL Ratio (NHR)?

A calculated ratio combining an inflammatory white-blood-cell count (neutrophils) with good (HDL) cholesterol.

This is a calculated value combining two routine results: it divides your neutrophil count (from a CBC) by your HDL cholesterol (from a lipid panel). Because neutrophils promote inflammation and HDL is anti-inflammatory, a higher NHR can be associated with greater inflammation and, in research, cardiovascular and metabolic risk, a lower value can be associated with a more favorable balance. It is a general marker, not a diagnosis.

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References

Official source "CBC-derived inflammatory ratios (Gasparyan, Ann Lab Med 2019)" PubMed. pubmed.ncbi.nlm.nih.gov/30809980.

About our sources

Clinical / professional

Medical societies, specialty colleges, and professional associations whose consensus statements reflect clinical practice standards.

Peer-reviewed research

Original research articles and systematic reviews published in indexed journals and verified through PubMed or DOI.

History of updates

Published · Jul 13, 2026
First published, calculated index, formula + sources independently fact-checked.

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