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Understand Castelli Risk Index II

Castelli Risk Index II

Heart & circulation markers

What the test generally measures, and what to ask about it.

Longetic keeps every lab and record you’ve had organized and easy to find, so your own Castelli Risk Index II values sit together on one chart and you walk into your next appointment prepared.

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Updated Jul 13, 2026

What is Castelli Risk Index II?

A calculated ratio of bad (LDL) cholesterol to good (HDL) cholesterol.

This is a calculated value from a standard lipid panel: it divides your LDL by your HDL (LDL divided by HDL). A higher ratio means more artery-clogging cholesterol relative to the protective kind and can be associated with greater cardiovascular risk, a lower ratio can be associated with a healthier balance. Castelli Risk Index II is mathematically the same as the LDL/HDL ratio.

This glossary entry is for informational purposes only and is not a substitute for professional medical advice. Read our Terms of Use.

References

Clinical "Cholesterol Levels: What You Need to Know" MedlinePlus (NIH/NLM). medlineplus.gov/cholesterollevelswhatyouneedtoknow.html.

About our sources

Clinical / professional

Medical societies, specialty colleges, and professional associations whose consensus statements reflect clinical practice standards.

Peer-reviewed research

Original research articles and systematic reviews published in indexed journals and verified through PubMed or DOI.

History of updates

Published · Jul 13, 2026
First published, calculated index, formula + sources independently fact-checked.

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