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Understand Albumin/Globulin (A/G) Ratio

Albumin/Globulin (A/G) Ratio

Liver markers

What the test generally measures, and what to ask about it.

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Updated Jul 13, 2026

What is Albumin/Globulin (A/G) Ratio?

A calculated comparison of the two main groups of blood proteins, albumin and globulins, usually reported with a total protein test.

The A/G ratio compares albumin (a protein made by the liver) with globulins (a group of proteins including antibodies), and it is calculated from a total protein and albumin measurement rather than measured directly. A lower ratio can be associated with conditions where albumin drops or globulins rise, such as some liver, kidney, or inflammatory conditions. A higher ratio can be associated with certain other imbalances. It is a general clue interpreted alongside the individual protein values, and comes automatically with the routine metabolic panel.

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References

Clinical "Total Protein and Albumin/Globulin (A/G) Ratio" MedlinePlus (NIH/NLM). medlineplus.gov/lab-tests/total-protein-and-albumin-globulin-a-g-ratio.

About our sources

Clinical / professional

Medical societies, specialty colleges, and professional associations whose consensus statements reflect clinical practice standards.

Peer-reviewed research

Original research articles and systematic reviews published in indexed journals and verified through PubMed or DOI.

History of updates

Published · Jul 13, 2026
First published; written and independently fact-checked against the cited sources.

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