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Understand Lp-PLA2 (Lipoprotein-Associated Phospholipase A2)

Lp-PLA2 (Lipoprotein-Associated Phospholipase A2)

Heart & circulation markers

What the test generally measures, and what to ask about it.

Longetic keeps every lab and record you’ve had organized and easy to find, so your own Lp-PLA2 (Lipoprotein-Associated Phospholipase A2) values sit together on one chart and you walk into your next appointment prepared.

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Updated Jul 13, 2026

What is Lp-PLA2 (Lipoprotein-Associated Phospholipase A2)?

An enzyme carried mostly on LDL that is linked to inflammation inside artery walls.

Lp-PLA2 is an enzyme that travels mainly with LDL cholesterol and is tied to the inflammation that can build up within artery walls. Higher levels have been associated in research with a greater risk of plaque-related cardiovascular events, which is why it is sometimes used as an add-on to help refine risk in people who are already at intermediate risk. It is an advanced, optional marker rather than part of a routine cardiovascular panel.

This glossary entry is for informational purposes only and is not a substitute for professional medical advice. Read our Terms of Use.

References

Peer-reviewed "A Review of Novel Cardiac Biomarkers: sST2, Lp-PLA2, MPO, and PCT" PubMed. doi.org/10.1155/2021/6258865.

About our sources

Clinical / professional

Medical societies, specialty colleges, and professional associations whose consensus statements reflect clinical practice standards.

Peer-reviewed research

Original research articles and systematic reviews published in indexed journals and verified through PubMed or DOI.

History of updates

Published · Jul 13, 2026
First published, written and independently fact-checked against the cited sources.

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