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Understand Lipoprotein(a) [Lp(a)]

Lipoprotein(a) [Lp(a)]

Heart & circulation markers

What the test generally measures, and what to ask about it.

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Updated Jul 13, 2026

What is Lipoprotein(a) [Lp(a)]?

A specific, largely inherited type of bad cholesterol particle that tends to be stickier than usual.

Your Lp(a) level is set mostly by your genes and stays fairly stable for life, so it can reveal an inherited layer of heart-and-stroke risk that a standard cholesterol test may miss. A higher Lp(a) can be associated with greater risk of heart disease, heart attack, and stroke even when other cholesterol numbers look fine. It is usually tested once rather than routinely; the 2018 ACC/AHA guideline treats an Lp(a) of 50 mg/dL (or 125 nmol/L) or above as a risk-enhancing factor and notes a relative indication to measure it with a family history of premature cardiovascular disease.

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References

Clinical "Lipoprotein (a) Blood Test: MedlinePlus Medical Test" MedlinePlus (NIH/NLM). medlineplus.gov/lab-tests/lipoprotein-a-blood-test.
Peer-reviewed "2018 ACC/AHA Guideline on the Management of Blood Cholesterol" Circulation (ACC/AHA). www.ahajournals.org/doi/10.1161/CIR.0000000000000625.

About our sources

Clinical / professional

Medical societies, specialty colleges, and professional associations whose consensus statements reflect clinical practice standards.

Peer-reviewed research

Original research articles and systematic reviews published in indexed journals and verified through PubMed or DOI.

History of updates

Published · Jul 13, 2026
First published; written and independently fact-checked against the cited sources.

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