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Understand DHEA-Sulfate (DHEA-S)

DHEA-Sulfate (DHEA-S)

Hormone markers

What the test generally measures, and what to ask about it.

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Summarize with AI
Updated Jul 13, 2026

What is DHEA-Sulfate (DHEA-S)?

An androgen (a male-type sex hormone) made mostly by the adrenal glands, present in both men and women.

DHEA-S is a steroid hormone produced mainly by the adrenal glands and serves as a building block for testosterone and estrogen; levels peak in young adulthood and decline with age. Because it comes largely from the adrenals, it is often used to check how those glands are working. Higher DHEA-S can be associated with adrenal conditions such as congenital adrenal hyperplasia, an adrenal tumor, or PCOS in women; lower levels can be associated with Addison disease or a pituitary problem. Results are interpreted with symptoms, age, sex, and other hormone tests.

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References

Clinical "DHEA Sulfate Test" MedlinePlus (NIH/NLM). medlineplus.gov/lab-tests/dhea-sulfate-test.

About our sources

Clinical / professional

Medical societies, specialty colleges, and professional associations whose consensus statements reflect clinical practice standards.

Peer-reviewed research

Original research articles and systematic reviews published in indexed journals and verified through PubMed or DOI.

History of updates

Published · Jul 13, 2026
First published; written and independently fact-checked against the cited sources.

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