Deamidated Gliadin IgG

What is Deamidated Gliadin IgG?

Antibodies useful in celiac screening for people with low IgA, since IgA-based celiac tests can be falsely negative.

Deamidated gliadin peptide (DGP) IgG antibodies target a modified form of gliadin, a wheat protein, that becomes more reactive to the immune system after a chemical change called deamidation. Because a portion of people have naturally low total IgA, which can make IgA-based celiac tests falsely negative, the IgG version of this test provides a useful alternative or supplement, particularly in young children and people with known IgA deficiency. Accurate results depend on consistent gluten intake before testing. A positive result supports further evaluation for celiac disease rather than confirming it outright, and is interpreted together with total IgA levels, other celiac antibodies, and digestive symptoms.

Tests often checked alongside this

• Deamidated Gliadin IgA — used together, particularly when total IgA is normal
• IgA (Immunoglobulin A) — checked to identify IgA deficiency, which affects test interpretation
• ESR and hs-CRP — general inflammation markers sometimes reviewed alongside

How this can show up in how you look and feel

• May be associated with digestive symptoms such as bloating or abdominal discomfort
• May be associated with fatigue
• May be associated with unintended weight or appetite changes
• May be associated with symptoms related to low iron

What can affect this marker

• Age
• Medications
• Lab variability between testing methods

What to track over time

• Whether results correlate with digestive symptoms over time
• How this result compares with total IgA and other celiac antibody testing
• Whether follow-up evaluation is considered based on this and related results

What to ask your doctor

• Was I eating enough gluten-containing food for this test to be accurate?
• Is this test being used because my total IgA is low?
• What would follow-up evaluation involve if this result is positive?
• How does this relate to my digestive symptoms?

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