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Understand Atypical Mononuclear Cells

Atypical Mononuclear Cells

Blood & blood cell markers

What the test generally measures, and what to ask about it.

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Updated Jul 13, 2026

What is Atypical Mononuclear Cells?

Unusual-looking mononuclear white blood cells that a lab may note on a blood smear.

Mononuclear cells are white blood cells with a single rounded nucleus, mainly lymphocytes and monocytes. When some look unusual under the microscope, a lab may report them as atypical mononuclear cells, shown as a share of the white blood cells. Their presence can be associated with the body reacting to a viral infection or other immune activity. This is a finding a lab sees on a blood smear rather than an automated result.

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References

"Blood Smear" Testing.com / Lab Tests Online (ADLM). www.testing.com/tests/blood-smear.

About our sources

Clinical / professional

Medical societies, specialty colleges, and professional associations whose consensus statements reflect clinical practice standards.

Peer-reviewed research

Original research articles and systematic reviews published in indexed journals and verified through PubMed or DOI.

History of updates

Published · Jul 13, 2026
First published, written from official sources (final verification pass pending).

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