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Adrenal Gland Disorders

What the test generally measures, and what to ask about it.

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Updated Jul 3, 2026

What is Adrenal Gland Disorders?

Conditions affecting the adrenal glands, which make cortisol and other essential hormones.

What are adrenal glands? Your adrenal glands are two small organs that sit on top of each kidney. The adrenal glands make different types of hormones you need to stay alive and healthy. Hormones are chemicals that travel in your bloodstream and control how different parts of your body work. The adrenal glands make the hormones cortisol, aldosterone, adrenaline, and noradrenaline. They also make hormones that your body uses to make sex hormones (estrogen and testosterone). All of these hormones do many important jobs, including: Turning food into energy and managing blood sugar levels Balancing salt and water Keeping blood pressure normal Responding to illness and stress (your "fight or flight" response) Timing when and how fast a child develops sexually Supporting pregnancy.

Tests often checked alongside this

How this can show up in how you look and feel

  • Unexplained weight gain or weight loss
  • Skin darkening or thinning, or unusual bruising
  • Fatigue that doesn't improve with rest
  • Changes in blood pressure
  • Symptoms vary widely depending on which hormone is affected and can be mistaken for other conditions

What can affect this marker

  • Chronic stress and sleep loss
  • Certain medications, like steroids
  • Autoimmune conditions
  • Pituitary signaling problems

What to track over time

  • Energy, weight and mood changes
  • Blood pressure and salt cravings
  • Symptom patterns over weeks
  • Related hormone test results

What to ask your doctor

  • Could my symptoms be adrenal-related?
  • Which hormone tests do I need?
  • Is this affecting my daily function?
  • Do I need specialist referral?

This glossary entry is for informational purposes only and is not a substitute for professional medical advice. Read our Terms of Use.

References

Clinical "Adrenal Gland Disorders" MedlinePlus, National Library of Medicine. medlineplus.gov/adrenalglanddisorders.html. Accessed Jul 3, 2026.
"Overview of the Adrenal Glands" MSD Manual, Consumer Version. www.msdmanuals.com/home/hormonal-and-metabolic-disorders/adrenal-gland-disorders/overview-of-the-adrenal-glands. Accessed Jul 7, 2026.

About our sources

Clinical / professional

Medical societies, specialty colleges, and professional associations whose consensus statements reflect clinical practice standards.

Peer-reviewed research

Original research articles and systematic reviews published in indexed journals and verified through PubMed or DOI.

History of updates

Published · Jul 3, 2026

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